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Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III

Appetite, cravings, and emotional eating Women disproportionately report emotional eating, stress-driven food seeking, and cyclical cravings that intensify around menstruation, perimenopause, and periods of elevated cortisol

So with a method like the patch where skin absorption is the primary absorption method, it seems the absorption of hormones is interfered with and causes likely lower drug levels and reduced efficacy Dr Lazorwitz explains

The FDA approved semaglutide for type 2 diabetes and weight loss in people with obesity or overweight with at least one weight-related health condition